Inhaled corticosteroids in obstructive airway disease.

Overlap Syndrome in Respiratory Medicine: Asthma and Chronic Obstructive Pulmonary Disease

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. However, the distinction between the two obstructive diseases is not always clear. Multiple epidemiological studies demonstrate that in elderly people with o...

Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis

BACKGROUND Whether inhaled corticosteroids suppress airway inflammation in chronic obstructive pulmonary disease (COPD) remains controversial. We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD. METHODS We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Databases for randomized, controlled clinical trials that used induced sputum ...

Effects of Inhaled Corticosteroids On Sputum Cell Counts In Stable Chronic Obstructive Pulmonary Disease: A Systematic Review And A Meta-Analysis (Running title: Corticosteroids And Airway Inflammation in COPD)

Do patients with COPD benefit from treatment with inhaled corticosteroids?

In the past few years, treatment with inhaled corticosteroids has become increasingly important in asthma [1, 2]. It appears that inflammation of the airway wall is a major pathophysiological mechanism underlying asthma [3], and perhaps also chronic obstructive pulmonary disease (COPD) [4]. Some long-term studies in asthmatic patients over 1 and 2 yrs have shown that maintenance treatment with ...

Risk of adverse gastrointestinal events from inhaled corticosteroids.

STUDY OBJECTIVE To determine whether patients prescribed inhaled corticosteroids are at risk for adverse gastrointestinal effects. DESIGN Retrospective cohort study. SETTING Urban health center with an academic affiliation. PATIENTS A total of 19,443 adults (mean age 31.8 yrs) with airways disease, defined as a diagnosis of asthma or chronic obstructive pulmonary disease, and who were pre...